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Assessing Delivered Dose of a Breath-Actuated Mesh Nebulizer: Breathing Simulator vs. NGI with Mixing Inlet Using Ipratropium Bromide

This study aimed to evaluate two in-vitro test methods when assessing delivered dose for a breath-actuated mesh nebulizer, including the method recognized by USP <1601>, which only relies on a breathing simulator, and the new method that incorporates a mixing inlet. The latter method further allowed analysis of APSD under a tidal breathing profile with ipratropium bromide.

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